Fig 1: A single intratumoral treatment with IL-31–neutralizing antibody reduces CTCL-induced pruritus.(A) Number of scratching bouts in 1 hour. Compared with IgG control antibody, IL-31–neutralizing antibody significantly reduced scratching at 1 hour, 3 hours, 5 hours, and 24 hours. Two-way ANOVA, P < 0.0001, F(1, 78)= 162.9. (B) Alloknesis induced by von Frey filament. Compared with IgG control antibody, IL-31–neutralizing antibody significantly reduced CTCL-induced alloknesis at 1 hour and 3 hours. Two-way ANOVA; P < 0.0001, F(1, 72)= 40.09. n = 6 for control IgG treatment; n = 9 for IL-31 antibody treatment. Behavior was assessed on CTCL day 25. **P < 0.01 and ****P < 0.0001, by Bonferroni’s multiple-comparison test.
Supplier Page from Abcam for Human IL-31 ELISA Kit